ApoB/LDL Ratio

The ApoB/LDL ratio is a way to estimate LDL particle size without specialized testing. Since each LDL particle carries exactly one ApoB molecule, comparing ApoB to LDL cholesterol reveals how many particles are carrying how much cholesterol. A high ApoB relative to LDL means more particles carrying less cholesterol each (small, dense LDL, which is higher risk). A low ApoB relative to LDL means fewer particles carrying more cholesterol each (large, buoyant LDL, which is lower risk).

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What can cause low ApoB/LDL?

A discordance where ApoB is high relative to LDL suggests a predominance of small, dense LDL particles. Insulin resistance, high triglycerides, and metabolic syndrome shift LDL toward smaller particles. Weight loss and triglyceride reduction (through diet, exercise, and reducing refined carbs) typically normalize this ratio.

This ratio helps explain why two people with the same LDL cholesterol can have very different cardiovascular risk. The person with more small, dense particles (higher ApoB/LDL) carries greater risk than the person with fewer large particles.

Biomarkers related to ApoB/LDL

ApoB/LDL is most highly correlated with LDL Cholesterol and Total Cholesterol. Here are the top biomarkers correlated with ApoB/LDL, based on 500,000 tests done by Empirical Health.

The percentage shows how strongly two biomarkers move together. A higher number means the relationship is stronger. Green = rises and falls together. Orange = one rises as the other falls.

ApoB/LDL test cost

You can test your ApoB/LDL for $190 as part of Empirical's comprehensive health panel, which includes 100 biomarkers.

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Where to test ApoB/LDL

You can measure your ApoB/LDL for at 2,200+ testing locations across the US. Click below and enter your zip code to browse locations near you.

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